Savoury Traveller

  • Home
  • Auto
  • Business
    • Business Ideas
  • Lifestyle
    • Entertainment
    • Family
    • Shopping
  • Fashion
  • Health
    • Beauty
  • Home Improvement
  • Main
  • Sport
  • Technology News
    • Apps Marketing
    • Digital Marketing
    • Internet Marketing
    • Social Media
    • Web Design
  • Travel
  • Wedding
  • Terms & Conditions
  • Contact Us
Home  /  Main  /  Could clinical trials contain falsified data?

Could clinical trials contain falsified data?

Tommo July 01, 2017 Main Comments are off

An investigation has been launched into some clinical trials as statistical patterns arouse suspicion over reliability. A large number of trials may contain falsified or incorrect data, according to a recent review of published papers.

Image Credit

Statistical tools

Consultant anaesthetist, John Carlisle, fromTorbay Hospital, undertook in-depth analysis. He reviewed data collected from over 5,000 clinical trials, which had been published over a period of fifteen years in the New England Journal of Medicine, Jama and six other journals specialising in anaesthesiology. He found a total of 90 trials which contained suspect statistical patterns. No matter how innocent, these patterns were unlikely to have appeared by chance alone, and this rate of error is concerning, especially considering results play a vital role in deciding the treatments paths of certain patients.

The statistical tools used to determine these results compared baseline data sets, including blood pressure, weight, gender and height, against known distributions of these different variables in random population samples. Significant variations from the expected data is an indication of data tampering, error or complete fabrication.

Image Credit

Serious allegations

In contrast to many other studies of this nature, Carlisle included as part of the review a list of the trials he identified, singling out authors and exposing them to potential criticism. Editors of the various journals involved now intend to approach associated authors and trigger more involved investigations where necessary.

The journal Anaesthesia published results of this latest analysis and editor-in-chief, Dr Andrew Klein, has called for the urgent review of studies identified within the report. He has also called for the adoption of similar methods of screening by all journals, as well as part of the entire trial process, including adaptive phase 1 studies (http://www.richmondpharmacology.com/adaptive-phase-i-studies.php).

Public Understanding of Risk Professor, Sir David Spiegelhalter, at the University of Cambridge, feels the publications must be scrutinised more closely. However, he has suggested caution when it comes to understanding the cause of such discrepancies at this stage.

The New England Journal of Medicine only accessed the cited papers upon publication of the report, however, they are carefully reviewing all information and consider the issue very serious. Jamal editor-in-chief, Howard Bauchner, will also be undertaking a full validity assessment of the allegations before determining next steps, including getting in touch with authors to give them the opportunity to respond to the allegations.

Previous Article
Next Article

About Author

Tommo

Related Posts

  • Tips For Building Muscle

    January 22, 2021
  • Television in the 1990’s.

    Television in the 1990’s.

    December 3, 2020
  • What is the Best Clothing to Go Hiking in?

    September 24, 2020

Tweets

Recent Posts

  • Tips For Building Muscle January 22, 2021
  • Naturally Beautiful Places that you Must See on a Trip to New Zealand January 14, 2021
  • What to Consider Before Starting a Renovation Project for the First Time January 7, 2021
  • What is Botox and its uses January 5, 2021

Popular Posts

  • Tips For Building Muscle January 22, 2021
  • diet
    Do not consume dairy products? Some alternatives to add calcium to your diet April 2, 2016
  • The mimic hormone affecting our health April 16, 2016
  • Four simple home business ideas for women! April 20, 2016

Random Posts

  • How to store your stove logs March 2, 2019
  • What Lurks Beneath Your Feet February 27, 2018
  • Shoulder Pain
    Back and Shoulder Pain June 8, 2016
  • Photographers Visit the New Forest for these reasons December 18, 2019

Categories

  • Auto
  • Beauty
  • Business
  • Business Ideas
  • Digital Marketing
  • Education
  • Entertainment
  • Family
  • Fashion
  • Health
  • Home Improvement
  • Internet Marketing
  • Lifestyle
  • Main
  • Reviews
  • Social Media
  • Sport
  • Technology News
  • Travel
  • Web Design
  • Wedding

Recent Posts

  • Tips For Building Muscle
  • Naturally Beautiful Places that you Must See on a Trip to New Zealand
  • What to Consider Before Starting a Renovation Project for the First Time
  • What is Botox and its uses
  • Should aspiring accountants go to university?

Tags

10 Tips to attract visitors affecting a gaming legend and saving tips Blizzard business calcium company configuration customers to your website dairy products deep learning diet Does it matter what processor DSM 6.0 Beta 2 Guide shared printers in the office: installation gym health HP mobile printing depth guide for printing Installation and commissioning Installing and configuring the network printer Internet Marketing IP addressing printers MediaTek mimic hormone mobile devices or remote money Optimize your site Other printing applications HP please register position in major search engines Print from anywhere Saving tips when using network printers Shoulder Pain Silicon society Software and functionalities Specifications and features success Synapse of Activision Tennis Serve Drills The future of mobility through the The living room to the Internet of Things video games Warcraft becomes much more